Shape analysis of subcortical nuclei in Huntington's disease, global versus local atrophy — Results from the TRACK-HD study

@article{Bogaard2011ShapeAO,
  title={Shape analysis of subcortical nuclei in Huntington's disease, global versus local atrophy — Results from the TRACK-HD study},
  author={S. Van Den Bogaard and Eve M. Dumas and Luca Ferrarini and Julien Milles and Mark A. van Buchem and Jeroen van der Grond and R. Roos},
  journal={Journal of the Neurological Sciences},
  year={2011},
  volume={307},
  pages={60-68}
}
Huntington's disease (HD) is characterized by brain atrophy. Localized atrophy of a specific structure could potentially be a more sensitive biomarker reflecting neuropathologic changes rather than global volume variation. We examined 90 TRACK-HD participants of which 30 were premanifest HD, 30 were manifest HD and 30 were controls. Using FMRIB's Integrated Registration and Segmentation Tool, segmentations were obtained for the pallidum, caudate nucleus, putamen, thalamus, accumbens nucleus… CONTINUE READING

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