Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation

  title={Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation},
  author={F. Raynaud and A. J{\'a}nossy and J. Dahl and F. Bertaso and J. Perroy and A. Varrault and M. Vidal and P. Worley and T. Boeckers and J. Bockaert and P. Marin and L. Fagni and V. Homburger},
  journal={The Journal of Neuroscience},
  pages={9699 - 9715}
  • F. Raynaud, A. Jánossy, +10 authors V. Homburger
  • Published 2013
  • Biology, Medicine
  • The Journal of Neuroscience
  • Synaptic long-term potentiation (LTP) is a key mechanism involved in learning and memory, and its alteration is associated with mental disorders. Shank3 is a major postsynaptic scaffolding protein that orchestrates dendritic spine morphogenesis, and mutations of this protein lead to mental retardation and autism spectrum disorders. In the present study we investigated the role of a new Shank3-associated protein in LTP. We identified the Rho-GAP interacting CIP4 homolog 2 (Rich2) as a new Shank3… CONTINUE READING
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