Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation

@article{Raynaud2013Shank3Rich2IR,
  title={Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation},
  author={F. Raynaud and A. J{\'a}nossy and J. Dahl and F. Bertaso and J. Perroy and A. Varrault and M. Vidal and P. Worley and T. Boeckers and J. Bockaert and P. Marin and L. Fagni and V. Homburger},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={9699 - 9715}
}
  • F. Raynaud, A. Jánossy, +10 authors V. Homburger
  • Published 2013
  • Biology, Medicine
  • The Journal of Neuroscience
  • Synaptic long-term potentiation (LTP) is a key mechanism involved in learning and memory, and its alteration is associated with mental disorders. Shank3 is a major postsynaptic scaffolding protein that orchestrates dendritic spine morphogenesis, and mutations of this protein lead to mental retardation and autism spectrum disorders. In the present study we investigated the role of a new Shank3-associated protein in LTP. We identified the Rho-GAP interacting CIP4 homolog 2 (Rich2) as a new Shank3… CONTINUE READING
    44 Citations
    Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
    • 22
    • PDF
    SNAP23–Kif5 complex controls mGlu1 receptor trafficking
    • 3
    • PDF
    Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
    • 22
    • PDF
    Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)
    • 24
    • PDF
    ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function.
    • 14
    • PDF

    References

    SHOWING 1-10 OF 62 REFERENCES
    Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
    • 263
    • PDF
    SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
    • 235
    • PDF
    Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.
    • 388
    • PDF
    The role of endosomal-recycling in long-term potentiation
    • 25
    Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
    • 960