Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.

@article{Sasaki2020Shank2BT,
  title={Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.},
  author={Kazunori Sasaki and Noriko Kojitani and Hiroko Hirose and Yohei Yoshihama and Hidefumi Suzuki and Miho Shimada and Ayumi Takayanagi and Akio Yamashita and Masa-aki Nakaya and Hisashi Hirano and Hidehisa Takahashi and Shigeo Ohno},
  journal={Cell reports},
  year={2020},
  volume={31 1},
  pages={
          107407
        }
}
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Correct apical clustering of Cno, an essential cue for setting up the apical-basal polarity axis, is regulated by active Rap1 acting both through, and independently of, the Cno Rap1-binding domain, which support a role for Canoe multimerization.
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization
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Results suggest that aPKC contributes to the establishment of epithelial cell polarity by promoting the transition of fibroblastic junctional structures into epithelia-specific asymmetric ones.
An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3
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TLDR
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