Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

@article{Naisbitt1999ShankAN,
  title={Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin},
  author={S. Naisbitt and Eunjoon Kim and J. Tu and B. Xiao and C. Sala and J. Valtschanoff and R. Weinberg and P. Worley and M. Sheng},
  journal={Neuron},
  year={1999},
  volume={23},
  pages={569-582}
}
NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic localization of Shank in neurons is inhibited by a GKAP splice variant that lacks the Shank… Expand
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Interaction of the Postsynaptic Density-95/Guanylate Kinase Domain-Associated Protein Complex with a Light Chain of Myosin-V and Dynein
Sharpin, a Novel Postsynaptic Density Protein That Directly Interacts with the Shank Family of Proteins
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 113 REFERENCES
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP
PDZ Proteins Organize Synaptic Signaling Pathways
SAPAPs
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
...
1
2
3
4
5
...