ShAR2beta, a divergent nicotinic acetylcholine receptor subunit from the blood fluke Schistosoma.

@article{Bentley2007ShAR2betaAD,
  title={ShAR2beta, a divergent nicotinic acetylcholine receptor subunit from the blood fluke Schistosoma.},
  author={Geoffrey N Bentley and Andrew K Jones and Alison Agnew},
  journal={Parasitology},
  year={2007},
  volume={134 Pt 6},
  pages={833-40}
}
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate the fast actions of the neurotransmitter, acetylcholine. Invertebrate nAChRs are of interest as they are targets of widely-selling insecticides and drugs that control nematode parasites. Here, we report the cloning of ShAR2beta, a candidate nAChR subunit from the blood fluke, Schistosoma haematobium, which is the third trematode nAChR subunit to be characterized. While ShAR2beta possesses key structural… CONTINUE READING