Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

Abstract

Craniofacial defects that occur through gene mutation during development increase vulnerability to eustachian tube dysfunction. These defects can lead to an increased incidence of otitis media. We examined the effects of a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) on the progression of otitis media and hearing impairment at various developmental stages… (More)
DOI: 10.1371/journal.pone.0022622

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