Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization.

@article{Martins2009Sgt1AC,
  title={Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization.},
  author={Torcato Martins and Andr{\'e} F Maia and Soren Steffensen and Claudio Enrique Sunkel},
  journal={The EMBO journal},
  year={2009},
  volume={28 3},
  pages={234-47}
}
Sgt1 was described previously in yeast and humans to be a Hsp90 co-chaperone and required for kinetochore assembly. We have identified a mutant allele of Sgt1 in Drosophila and characterized its function. Mutations in sgt1 do not affect overall kinetochore assembly or spindle assembly checkpoint. sgt1 mutant cells enter less frequently into mitosis and arrest in a prometaphase-like state. Mutations in sgt1 severely compromise the organization and function of the mitotic apparatus. In these… CONTINUE READING