SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda.

@article{Huang2013SfDroncAI,
  title={SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda.},
  author={Ning Huang and Srgjan Civciristov and Christine J Hawkins and Rollie J. Clem},
  journal={Insect biochemistry and molecular biology},
  year={2013},
  volume={43 5},
  pages={444-54}
}
Initiator caspases are the first caspases that are activated following an apoptotic stimulus, and are responsible for cleaving and activating downstream effector caspases, which directly cause apoptosis. We have cloned a cDNA encoding an ortholog of the initiator caspase Dronc in the lepidopteran insect Spodoptera frugiperda. The SfDronc cDNA encodes a predicted protein of 447 amino acids with a molecular weight of 51 kDa. Overexpression of SfDronc induced apoptosis in Sf9 cells, while partial… CONTINUE READING

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