Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

@article{Sakamoto2008SexuallyDG,
  title={Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions},
  author={Hirotaka Sakamoto and Ken-ichi Matsuda and Damian G. Zuloaga and Hisayuki Hongu and Etsuko Wada and Keiji Wada and Cynthia Lee Jordan and S Marc Breedlove and Mitsuhiro Kawata},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={634-636}
}
Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive… CONTINUE READING

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