Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behavior after early deprivation.

@article{Zimmerberg2004SexuallyDE,
  title={Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behavior after early deprivation.},
  author={Betty Zimmerberg and Elizabeth W Kajunski},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={78 3},
  pages={465-71}
}
Stress early in life exerts persistent detrimental effects on brain development. In this experiment, a rodent model of child neglect, early deprivation (ED), was used to investigate the role of the neurosteroid allopregnanolone [AlloP; 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP)] in the development of anxiety behavior. Subjects were either undisturbed controls or ED: separated individually for 6 h per day from postnatal day (PN) 2 to 6. Control and ED subjects were also either… CONTINUE READING

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Pflügers Archiv - European Journal of Physiology • 2013
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