Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model

@article{Mohsen2017SexuallyDD,
  title={Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model},
  author={Zaid Mohsen and Hosung Sim and David Garc{\'i}a-Galiano and Xingfa Han and Nicole H Bellefontaine and Thomas L Saunders and Carol F Elias},
  journal={Brain Structure and Function},
  year={2017},
  volume={222},
  pages={4111-4129}
}
Prokineticin receptor 2 (PROKR2) is predominantly expressed in the mammalian central nervous system. Loss-of-function mutations of PROKR2 in humans are associated with Kallmann syndrome due to the disruption of gonadotropin releasing hormone neuronal migration and deficient olfactory bulb morphogenesis. PROKR2 has been also implicated in the neuroendocrine control of GnRH neurons post-migration and other physiological systems. However, the brain circuitry and mechanisms associated with these… CONTINUE READING