Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXR alpha) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice

Abstract

Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sexspecific manner due to distinct patterns of hepatic gene expression between males and females. Regulation for the majority of these genes is under control of Nuclear Receptors (NRs). Retinoid X Receptor alpha (RXRa) is an obligate partner for… (More)

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