Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors.

@article{Hecht1998SexualTO,
  title={Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors.},
  author={Frederick M. Hecht and Robert Michael Grant and Christos J. Petropoulos and Belinda Dillon and Michael A. Chesney and He Tian and Nicholas S. Hellmann and N I Bandrapalli and Laura Digilio and Bernard M. Branson and Jim O Kahn},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 5},
  pages={
          307-11
        }
}
Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow disease progression.1 The development of resistance to these drugs, however, limits the benefit of such treatments.2,3 There have been reports of the transmission of HIV-1 variants that are resistant to nucleoside and non-nucleoside inhibitors of reverse transcriptase.4–9 The transmission of HIV-1 variants that are resistant to protease… CONTINUE READING
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