Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.

  title={Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.},
  author={Zoe Zhang and T.. Schuler and Mary L. Zupancic and Steve Wietgrefe and Katherine A Staskus and Keith A Reimann and Todd A. Reinhart and Michael John Rogan and Winston P Cavert and Christopher J Miller and Ronald S Veazey and Daan W. Notermans and Susan Little and Sven A. Danner and Douglas D. Richman and Diane Havlir and Jeffrey W. Wong and Holly Lynn Jordan and Timothy W Schacker and Paul Racz and Klara Tenner-Racz and Norman L. Letvin and Steven Wolinsky and Ashley T Haase},
  volume={286 5443},
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 421 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 341 citations

422 Citations

Citations per Year
Semantic Scholar estimates that this publication has 422 citations based on the available data.

See our FAQ for additional information.