Sexual hormones: Effects on cardiac and mitochondrial activity after ischemia–reperfusion in adult rats. Gender difference

@article{Pavn2012SexualHE,
  title={Sexual hormones: Effects on cardiac and mitochondrial activity after ischemia–reperfusion in adult rats. Gender difference},
  author={Natalia Pav{\'o}n and Eduardo Mart{\'i}nez-Abundis and Luz Hern{\'a}ndez and Juan Carlos Gallardo-P{\'e}rez and Carolina {\'A}lvarez‐Delgado and Marco Cerb{\'o}n and Israel P{\'e}rez-Torres and Alberto Aranda and Edmundo Ch{\'a}vez},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2012},
  volume={132},
  pages={135-146}
}
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References

SHOWING 1-10 OF 40 REFERENCES
Gender differences in post-infarction hypertrophy in end-stage failing hearts.
In hyperthyroid rats octylguanidine protects the heart from reperfusion damage
TLDR
It is concluded that octylguanidine inhibits the hypersensitivity of the hyperthyroid myocardium to undergo reperfusion damage due to its inhibitory action on the permeability transition pore.
Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens
Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone.
TLDR
It is concluded that testosterone plays an important role in modulating cardiac repolarization and the changes observed in castrated men may be reverted by testosterone.
Estrogen Receptor β as a Mitochondrial Vulnerability Factor*
We recently demonstrated mitochondrial localization of estrogen receptor β (ERβ). We herein confirm the mitochondrial localization of ERβ by the loss of mitochondrial ERβ immunoreactivity in ERβ
Functional estrogen receptors in the mitochondria of breast cancer cells.
TLDR
It is reported that in MCF-7, estrogen inhibits UV radiation-induced cytochrome C release, the decrease of the mitochondrial membrane potential, and apoptotic cell death, and E2 (estradiol) inhibited all these events, directly acting in mitochondria to inhibit mROS by rapidly up-regulating manganese superoxide dismutase activity.
The mitochondrial origin of postischemic arrhythmias.
TLDR
These findings directly link instability of DeltaPsi(m) to the heterogeneous electrophysiological substrate of the postischemic heart and highlight the mitochondrial membrane as a new therapeutic target for arrhythmia prevention in ischemic heart disease.
...
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