Sexual factors and prostate cancer

  title={Sexual factors and prostate cancer},
  author={G. G. Giles and Gianluca Severi and Dallas R. English and Margaret R. E. McCredie and Ron Borland and Peter Boyle and J. L. Hopper},
  journal={BJU International},
To assess whether prostate cancer might be related to hormone levels and, by inference, to differences in sexual activity. 

Sexual activity and prostate cancer risk in men diagnosed at a younger age

To examine, in a case‐control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at ≤60 years old.

Prostate Cancer and Inflammatory Genes

A large number of patients with known or suspected cases of prostate cancer are seeking medical treatment for inflammation, which is an important component in the aetiology of the disease.

Risk factors for prostate cancer

The identification and further characterization of risk modifiers might provide insight into treatment and prevention of prostate cancer.

Sexual activity and the risk of prostate cancer: Review article.

Frequent ejaculation seems to be protective from the development of prostate cancer, excluding the risk of sexually transmitted infections, and multiple sexual partners may be Protective from prostate cancer.

The association between sexual function and prostate cancer risk in US veterans

Higher sexual function was associated with a decreased risk of overall and high-grade prostate cancer among men undergoing prostate biopsy, adjusting for multiple demographic and clinical characteristics.

Circulating sex hormones play no role in the association between sexual activity and the risk of prostate cancer.

High SA as well as TT and FT were protective against PC and the protective effect of high SA was independent from circulating levels of SHs.

Relationship between Prostate Cancer and Sexual Activity: A Case-Control study

Different impact of sexual activity in different age in patients with prostate cancer is indicated, especially meta-analysis or systematic review, should be conducted to clarify this issue.

Regarding prostate-specific antigen: let's not shoot the messenger.

It is proposed that the actual reduction in prostate tissue PSA concentration over time might result in the promotion of high-grade prostate cancer.



Prostate‐specific antigen testing in Australia and association with prostate cancer incidence in New South Wales

To describe patterns and trends in prostate‐specific antigen (PSA) testing in Australia and assess its role in the increasing incidence of prostate cancer, a large number of patients diagnosed with prostate cancer in Australia are receiving PSA testing.

Prostate cancer.

Either potency-saving subcapsular prostatectomy or radiation therapy is effective in treating localized disease and new prospects for hormonal therapy of metastatic prostate cancer include antiandrogens and gonadotropin-releasing analogs.

Sexual factors and the risk of prostate cancer.

A population-based case-control study of prostate cancer was performed in King County, Washington, in White men and Black men aged 40-64 years, and found no relation between sexual orientation and prostate cancer, although the number of men who had sex with men was small.

Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency

The gender‐identity, psychosexual orientation and sexual activity of a man with a congenital lack of oestradiol resulting from an inactivating mutation of the aromatase P450 gene was investigated.

Prospective study of sex hormone levels and risk of prostate cancer.

High levels of circulating testosterone and low levels of SHBG-both within normal endogenous ranges-are associated with increased risks of prostate cancer, and circulating levels of DHT and AAG do not appear to be strongly related to prostate cancer risk.

Androgenetic alopecia and prostate cancer: findings from an Australian case-control study.

  • G. GilesG. Severi J. Hopper
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
The data suggest an association between prostate cancer and vertex baldness; this association between the pattern of AA and prostate cancer points to shared androgen pathways that are worthy of additional investigation.

The role of steroid hormones in prostate carcinogenesis.

  • M. Bosland
  • Medicine, Biology
    Journal of the National Cancer Institute. Monographs
  • 2000
A multifactorial general hypothesis of prostate carcinogenesis emerges with androgens as strong tumor promoters acting via androgen receptor-mediated mechanisms to enhance the carcinogenic activity of strong endogenous genotoxic carcinogens and possible weak environmental carcinogens of unknown nature.

Risk factors for prostate cancer: a case‐control study in Greece

There was evidence that some aspect of urban life may increase the risk for PC and a suggestion that sexual activity in early adulthood may be inversely associated with this risk, and there was evidence for a positive association between vertex baldness, tobacco smoking and drinking of coffee or alcoholic beverages.

A cohort study of mortality from cancer of the prostate in Catholic priests.

Support for the third theory comes from a number of epidemiological findings, including marital status, evermarried, particularly divorced men, being at higher risk than never-married men, and an above-average risk of prostatic cancer in men who have sexual intercourse more often than average and have more than one sex partner.

Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada

There was a positive association between energy intake and risk of prostate cancer, such that men at the uppermost quartile level of energy intake had a 75 percent increase in risk, and there was no clear association between the non-energy effects of total fat and monounsaturated fat intake and prostate cancer risk.