Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.

  title={Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.},
  author={Kalamegam Gauthaman and Adaikan P Ganesan and Rout Nutan Prasad},
  journal={Journal of alternative and complementary medicine},
  volume={9 2},
OBJECTIVE Apart from its claims for improvement of sexual functions in men, the puncturevine plant (Tribulus terrestris: TT) has long been considered as an energizer and vitalizer in the indigenous system of medicine. Sexual behavior and intracavernous pressure (ICP) measurements were taken in rats to scientifically validate the claim of TT [containing protodioscin (PTN)] as an aphrodisiac. MATERIALS AND METHODS Forty sexually mature male Sprague-Dawley rats were randomly divided into four… 

Figures and Tables from this paper

Study of Furostenol Glycoside Fraction of Tribulus terresteris. on Male Sexual Function in Rats

The furostenol glycoside fraction of Tribulus terrestris exhibited good aphrodisiac properties and was found to increase orientational activity parameters such as licking and ano-and genital grooming and decreased climbing and nongential grooming by male rats indicating increased sexual stimulation and lack of interest toward external environment after treatment with TT-FG.

Use of Tribulus terrestris and Lepidium meyenii extract in rats: reproductive, biochemical and body parameters

It is concluded that the association of T. terrestris and L. meyenii has positive effects on serum testosterone, sperm concentration and epididymal morphology, with no evidence of effects in the testis, liver, spleen and kidneys.

Tribulus terrestris Protects against Male Reproductive Damage Induced by Cyclophosphamide in Mice

The role of TT dry extract is highlighted to ameliorate the alterations induced by CP administration in mice testes, probably due to the presence of protodioscin.

Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats.

The results are indicative of prosexual stimulatory potentials of Bulbine natalensis in male rats and may be used in the management of disorders of desire/libido, premature ejaculation and erectile dysfunction in males.

Effects of Tribuls Terrestris (Quttub) and Clomiphene Citrate on Ovaries of Female Mice; Histological and Histochemical Study

Tribuls terrestris can stimulate ovulation when given alone, and oppose the anti-ovulatory effect of clomiphene and resume ovulating when given in combination with it.

Alternative treatment of ovarian cysts with Tribulus terrestris extract: a rat model.

It can be concluded that T. terrestris have a luteinizing effect on ovarian Cysts, which may relate to its gonadotropin-like activity; also, a high dose of the extract can efficiently remove ovarian cysts and resume ovarian activity.

The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men.


Tribulus terrestris increases the levels of LH when administered in appropriate doses when applied to male Sprague Dawley rats.

Dose-dependent effects of Asparagus adscendens root (AARR) extract on the anabolic, reproductive, and sexual behavioral activity in rats

The results indicate increased anabolic, reproductive, and sexual activities by AARR treatment, and provide scientific rationale for its traditional use as an aphrodisiac or for sexual disorders.



Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.

The relaxant responses to acetylcholine, nitroglycerin and EFS and the lack of such effect on the contractile response to noradrenaline and histamine indicate that PTN has a proerectile activity, which may account for its claims as an aphrodisiac.

Protodioscin from herbal plant Tribulus terrestris L improves the male sexual functions, probably via DHEA

A significant increase of DHEA-S levels in diabetic and non-di diabetic subjects after treatment, and a significant increase in the frequency of successful intercourse by 60% in both the diabetic andNon-diabetic groups with or without ED.

History of herbal medicines with an insight on the pharmacological properties of Tribulus terrestris

In this article, the various pharmacological effects of TT have been reviewed and the studies based on TT extract in relation to male erectile dysfunction have been summarized.

Effects of tetrabenazine on the copulatory behavior of male rats.

  • D. Dewsbury
  • Biology, Psychology
    European journal of pharmacology
  • 1972

The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat.

In reflex erection, erectile response to ES and penile NOS activity in the rat, T seems to be first converted to DHT, the more active androgen modality.

Dehydroepiandrosterone (DHEA): a fountain of youth?

  • E. Baulieu
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 1996
0 N SEPTEMBER 29 1675, the Marquise de Sevigne, then about 50, wrote in one her famous Letters; “. . . my health is the same as six years ago: I do not know where the Fountain of Youth (Fontaine de

Rat model for the study of penile erection: pharmacologic and electrical-stimulation parameters.

A modified rat model is used for the study of the mechanisms of penile erection and phentolamine and norepinephrine increased systemic blood pressure, whereas phenylephrine decreased the intracavernous pressure in response to electrostimulation significantly.

Interactional effects of pudendal nerve section and social restriction on male rat sexual behavior