Sexual dysfunction: Postorgasmic illness syndrome

@article{Farley2011SexualDP,
  title={Sexual dysfunction: Postorgasmic illness syndrome},
  author={Suzanne J. Farley},
  journal={Nature Reviews Urology},
  year={2011},
  volume={8},
  pages={121-121}
}
  • S. Farley
  • Published 1 March 2011
  • Medicine
  • Nature Reviews Urology
New evidence supports the hypothesis that postorgasmic illness syndrome (POIS) in men involves a hyper-reactive immune response of the mucosal epithelium that lines the urinary tract to seminal fluid. 
6 Citations

References

SHOWING 1-2 OF 2 REFERENCES

Postorgasmic Illness Syndrome (POIS) in 45 Dutch caucasian males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1).

TLDR
The combination of allergic and systemic flu-like reactions post-ejaculation together with a positive skin-prick test in the majority of males underscores the hypothesis of an "immunogenic" etiology of POIS, e.g., that POIS is caused by Type-1 and Type-IV allergy to the males' own semen, as soon it is triggered by ejaculation.

Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2).

TLDR
Two males with POIS were successfully treated by hyposensitization with autologous semen, which supports an immunogenic/allergic etiology and underscores the clinical implication for immunological sexual medicine.