Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

@article{Raz2005SexualDO,
  title={Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1},
  author={P. Raz and E. Nasatzky and B. Boyan and A. Ornoy and Z. Schwartz},
  journal={Journal of Cellular Biochemistry},
  year={2005},
  volume={95}
}
  • P. Raz, E. Nasatzky, +2 authors Z. Schwartz
  • Published 2005
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Rat costochondral growth plate chondrocytes exhibit sex‐specific and cell maturation dependent responses to testosterone. Only male cells respond to testosterone, although testosterone receptors are present in both male and female cells, suggesting other mechanisms are involved. We examined the hypothesis that the sex‐specific response of rat costochondral cartilage cells to testosterone requires further metabolism of the hormone to dihydrotestosterone (DHT). Resting zone (RC) and growth zone… CONTINUE READING
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