Sexual dimorphism of AMBRA1-related autistic features in human and mouse

@inproceedings{Mitjans2017SexualDO,
  title={Sexual dimorphism of AMBRA1-related autistic features in human and mouse},
  author={Marina Mitjans and Matthias Begemann and Anes Ju and Ekrem Dere and Liane W{\"u}stefeld and Susanne Hofer and I Hassouna and J Balkenhol and Beatriz Oliveira and Sandra Van der Auwera and R Tammer and Kurt Hammerschmidt and Henry V{\"o}lzke and Georg Homuth and Francesco Cecconi and Kamal Chowdhury and Hans J{\"o}rgen Grabe and Jens Frahm and Susann Boretius and Thomas Dandekar and Hannelore Ehrenreich},
  booktitle={Translational Psychiatry},
  year={2017}
}
Ambra1 is linked to autophagy and neurodevelopment. Heterozygous Ambra1 deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen in female mice only, combined with stronger Ambra1 protein reduction in brain compared to males. However, significance of AMBRA1 for autistic phenotypes in humans and… CONTINUE READING