Sexual dimorphism and brain lateralization impact behavioral and histological outcomes following hypoxia–ischemia in P3 and P7 rats

@article{Sanches2015SexualDA,
  title={Sexual dimorphism and brain lateralization impact behavioral and histological outcomes following hypoxia–ischemia in P3 and P7 rats},
  author={Edgar Sanches and Nice Sarmento Arteni and Fabr{\'i}cio Nicola and Dirceu Aristimunha and C. A. Netto},
  journal={Neuroscience},
  year={2015},
  volume={290},
  pages={581-593}
}
Neonatal cerebral hypoxia-ischemia (HI) is a major cause of neurological disorders and the most common cause of death and permanent disability worldwide, affecting 1-2/1000 live term births and up to 60% of preterm births. The Levine-Rice is the main experimental HI model; however, critical variables such as the age of animals, sex and hemisphere damaged still receive little attention in experimental design. We here investigated the influence of sex and hemisphere injured on the functional… CONTINUE READING
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