Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders

@article{Bao2011SexualDO,
  title={Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders},
  author={Ai-min Bao and Dick F. Swaab},
  journal={Frontiers in Neuroendocrinology},
  year={2011},
  volume={32},
  pages={214-226}
}
  • A. Bao, D. Swaab
  • Published 1 April 2011
  • Medicine, Psychology
  • Frontiers in Neuroendocrinology
During the intrauterine period a testosterone surge masculinizes the fetal brain, whereas the absence of such a surge results in a feminine brain. As sexual differentiation of the brain takes place at a much later stage in development than sexual differentiation of the genitals, these two processes can be influenced independently of each other. Sex differences in cognition, gender identity (an individual's perception of their own sexual identity), sexual orientation (heterosexuality… 
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References

SHOWING 1-10 OF 152 REFERENCES
Sexual differentiation of the human brain in relation to gender identity and sexual orientation.
TLDR
During the intrauterine period the fetal brain develops in the male direction through a direct action of testosterone on the developing nerve cells, or in the female direction through the absence of this hormone surge, so that gender identity and sexual orientation are programmed into their brain structures when the authors are still in the womb.
Sex Differences in the Brain, Behavior, and Neuropsychiatric Disorders
  • A. Bao, D. Swaab
  • Psychology, Medicine
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2010
TLDR
Structural and functional sex Differences in brain areas, together with changes in sex hormone levels and their receptors in development and adulthood, are closely related to sex differences in behavior and neuropsychiatric disorders.
Sexual orientation and its basis in brain structure and function
  • D. Swaab
  • Psychology, Medicine
    Proceedings of the National Academy of Sciences
  • 2008
TLDR
It is reported that hemispheric ratios, as well as patterns of amygdala connectivity, were sex-atypical in homosexual individuals, with HoM exhibiting more female patterns than HeM and HoW showing more male-like features than HeW.
Sexual Differentiation of the Bed Nucleus of the Stria Terminalis in Humans May Extend into Adulthood
TLDR
It is found that the sexually dimorphic central subdivision of the bed nucleus of the stria terminalis was larger and contains more neurons in men than in women in adulthood, showing that sexual differentiation of the human brain may extend into the adulthood.
The human hypothalamus in relation to gender and sexual orientation.
TLDR
Preliminary data suggest that the suprachiasmatic nucleus (SCN) is large and the SDN small in primary male-to-female transsexuals and that the SCN is small and theSDN large in secondary male- to- female transsexuals, but more data have to be collected to confirm this observation.
A sex difference in the human brain and its relation to transsexuality
TLDR
This study is the first to show a female brain structure in genetically male transsexuals and supports the hypothesis that gender identity develops as a result of an interaction between the developing brain and sex hormones.
Sexual Differentiation of Behaviour in Monkeys: Role of Prenatal Hormones
TLDR
Research is reviewed, including Robert W. Goy's pioneering work with rhesus monkeys, which manipulated prenatal hormones at different gestation times and demonstrated that genital anatomy and specific behaviours are independently sexually differentiated, to demonstrate that sexual differentiation arises from complex interactions.
Sex differences in brain and behavior: hormones versus genes.
TLDR
In this chapter, it is argued that genetic factors play a role in sexually dimorphic traits such as the number of dopaminergic cells in the mesencephalon, aggression, and sexual orientation, independently from gonadal hormones.
Sexual differentiation of the human brain. A historical perspective.
TLDR
Staining with antibodies raised to vasopressin enables morphometric studies on this hypothalamic clock that reveal that the suprachiasmatic nucleus in women tends to be larger in its cranio-caudal diameter while in men it has a larger maximal diameter in the middle of the nucleus.
Sexual differentiation of the human hypothalamus: ontogeny of the sexually dimorphic nucleus of the preoptic area.
TLDR
The present life span study on the human sexually dimorphic nucleus revealed that at the age of 2-4 years the SDN cell number reaches a peak value, and that only after this age sexual differentiation becomes manifest.
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1
2
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4
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