Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.

@article{Menke2003SexualDO,
  title={Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave.},
  author={Douglas B Menke and Jana Koubova and David C Page},
  journal={Developmental biology},
  year={2003},
  volume={262 2},
  pages={303-12}
}
Differentiation of mouse embryonic germ cells as male or female is dependent on the somatic environment of the gonad rather than the sex chromosome constitution of the germ cell. However, little is known about the initiation of germ cell sexual differentiation. Here, we traced the initiation of germ cell sexual differentiation in XX gonads using the Stra8 gene, which we demonstrate is an early molecular marker of female germ cell development. Stra8 is upregulated in embryonic germ cells of XX… CONTINUE READING
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