Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating

  title={Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating},
  author={Daisuke Yamamoto and Yoshiro Nakano},
  journal={Cellular and Molecular Life Sciences CMLS},
Abstract. The study of Drosophila melanogaster by a combination of forward genetics with specific mutants, and reverse genetics, in which a given gene is expressed in an appropriate brain area to test its effect on behavior, provides a unique opportunity to explore the causal relationship between a particular gene, its function in the cell and the behavioral outcome at the organismic level. Enhanced male-to-male courtship has been shown to occur as a result of mutations in several different… 

A gene necessary for normal male courtship, yellow, acts downstream of fruitless in the Drosophila melanogaster larval brain.

It is demonstrated that the yellow (y) gene is genetically downstream of fru in the 3(rd)-instar larval brain and suggested that y is a downstream member of the fru branch of the D. melanogaster sex determination hierarchy, where it plays a currently unknown role in the development of adult male wing extension during courtship.

Genetic Analysis of chaste, a New Mutation of Drosophila melanogaster Characterized by Extremely Low Female Sexual Receptivity

It is suggested that the mbl gene function is required for the normal development of neural substrates that regulate female sexual receptivity and disappears in the presence of a mutant copy of zeste (z), a gene encoding a protein that mediates transvection.

A cis-regulatory Sequence Within the yellow Locus of Drosophila melanogaster Required for Normal Male Mating Success

Visualization of gene action via GFP and a Yellow antibody suggests that the MRS directs y transcription in a small number of cells in the third instar CNS, the developmental stage previously implicated in the role of y with regard to male courtship behavior.

New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs.

The reproductive functions regulated by fruitless are expanded in their scope, encompassing not only the earliest stages of courtship behavior along with almost all subsequent steps in the behavioral sequence, but also more than one component of the culminating events.

Expression Level of sarah, a Homolog of DSCR1, Is Critical for Ovulation and Female Courtship Behavior in Drosophila melanogaster

Results indicate that the expression level of sra is critical for ovulation and female courtship behavior, including their postmating changes, which are physiologically coupled.

Evolution of sexual dimorphism in the olfactory brain of Hawaiian Drosophila

It is suggested that a defined set of glomeruli in Drosophila can enlarge in response to sex–determination genetic signals, the mutations of which may result in species differences in sexual dimorphism of the brain.

Abnormalities of Male-Specific FRU Protein and Serotonin Expression in the CNS of fruitless Mutants inDrosophila

The fruitless gene in Drosophilaproduces male-specific protein (FRUM) involved in the control of courtship was examined and double-labeling uncovered no coexpression of FRUMand 5-HT in brain neurons, yet, a newly identified set of sexually dimorphic FRUM/5-HT-positive neurons was identified in the abdominal ganglion of adult males.

The Genetic Basis of Female Mate Preference and Species Isolation in Drosophila

Although females appear to use the same traits for both within- and between-species female mate choice, there seems to be a different genetic basis underlying these choices, and most genomic regions that cause females to reject heterospecific males fall within areas of low recombination.

Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila.

Those of us who are drawn to such studies, or have long performed them, are intrigued by the mating dance itself and are sustained by an article of faith that fly genetics will open windows through which the authors might glimpse some of the mysteries of maleness and femaleness.



Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster.

  • J. BeloteB. S. Baker
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.

Voila, a New Drosophila Courtship Variant that Affects the Nervous System: Behavioral, Neural, and Genetic Characterization

In Drosophila melanogaster, a specific PGAL4 transposon induces the Voila1 genetic variant and produces multiple phenotypes, which have multiple behavioral effects.

Phenotypic and molecular characterization of croaker, a new mating behavior mutant of Drosophila melanogaster.

It is demonstrated that neuromuscular transmission and Ca++ electrogenesis in the muscle fibers are not impaired by the croaker mutation, and genomic DNA surrounding the P-element insertion site was cloned by plasmid rescue and subsequent screening of a cosmid library.

Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics.

In gynandromorphs of Drosophila, a detailed examination was made of the association between male courtship behavior and the chromosomal genotype of various parts of the central nervous system. Mosaic

The mating of a fly.

Courtship in Drosophila is influenced by a wide variety of genes, in that many different kinds of pleiotropic mutations lead to defective courtship. This may seem to be a truism, but the broad

Icebox, a recessive X-linked mutation in Drosophila causing low sexual receptivity.

These characteristics suggest that ibx does not cause sensory or motor defects, and males and females mutant for ibx have normal egg-to-adult survival and appear normal in several "general" behavioral traits including olfaction, phototaxis, locomotor activity, and heartbeat.

Genetic dissection of sexual behavior in Drosophila melanogaster.

This review presents current understandings of mating behavior obtained by such molecular and cellular approaches and provides an overview of future directions of research in behavioral genetics.