Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms

  title={Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms},
  author={B. Cooke and C. D. Hegstrom and L. Villeneuve and S. M. Breedlove},
  journal={Frontiers in Neuroendocrinology},
  • B. Cooke, C. D. Hegstrom, +1 author S. M. Breedlove
  • Published 1998
  • Biology, Medicine
  • Frontiers in Neuroendocrinology
  • A wide variety of sexual dimorphisms, structural differences between the sexes, have been described in the brains of many vertebrate species, including humans. In animal models of neural sexual dimorphism, gonadal steroid hormones, specifically androgens, play a crucial role in engendering these differences by masculinizing the nervous system of males. Usually, the androgen must act early in life, often during the fetal period to masculinize the nervous system and behavior. However, there are a… CONTINUE READING
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