Sexual Differentiation of Rat Hepatic Bile Salt Sulfotransferase Isoenzymes

@article{Kane1988SexualDO,
  title={Sexual Differentiation of Rat Hepatic Bile Salt Sulfotransferase Isoenzymes},
  author={Robert E. Kane and Lee J Chen and John J Herbst and Michael M Thaler},
  journal={Pediatric Research},
  year={1988},
  volume={24},
  pages={247-253}
}
ABSTRACT: The mature female rat has three times the hepatic bile salt sulfotransferase (BSS) activity compared with male rats. This study examined the changes in two hepatic BSS isoenzyme activities during sexual maturation, and the role of estrogen in development of sex differences in BSS activities in mature rats. DEAE-Sephadex A-50 chromatography of hepatic cytosol from prepubescent pups revealed that more than 90% of total BSS activity was due to BSS I activity relative to BSS II, similar… CONTINUE READING