Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia.

@article{Nordenstrm2002SextypedTP,
  title={Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia.},
  author={Anna Nordenstr{\"o}m and Anna Servin and Gunilla Bohlin and Agne Larsson and Anna Wedell},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 11},
  pages={5119-24}
}
Previous studies have shown that girls with congenital adrenal hyperplasia (CAH), a syndrome resulting in overproduction of adrenal androgens from early fetal life, are behaviorally masculinized. We studied play with toys in a structured play situation and correlated the results with disease severity, assessed by CYP21 genotyping, and age at diagnosis. Girls with CAH played more with masculine toys than controls when playing alone. In addition, we could demonstrate a dose-response relationship… CONTINUE READING
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