Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution

  title={Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution},
  author={Inge Lamote and Evelyne Meyer and Anne-Marie Massart-Le{\"e}n and Christian Burvenich},

3 – Mammary Gland

Role of ovarian secretions in mammary gland development and function in ruminants.

The role and the importance of ovarian steroids on mammary gland and on MECs is described and ovarian steroids appear to be key regulators of the different stages of mammogenesis and mammary function.

Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation

The concept of cellular plasticity in normal breast morphogenesis and cancer, and how the stromal environment plays a vital role in cancer initiation and progression is discussed.

Age-Related Changes in the Epithelial and Stromal Compartments of the Mammary Gland in Normocalcemic Mice Lacking the Vitamin D3 Receptor

Developmental studies indicate that, under normocalcemic conditions, loss of VDR signaling is associated with age-related estrogen deficiency, disruption of epithelial ductal branching, abnormal energy expenditure and atrophy of the mammary adipose compartment.

Growth hormone alters components related to differentiation, metabolism and milk synthesis and secretion in MAC-T cells

Results indicate that GH is an important factor in inducing a lactogenic phenotype in the MAC-T cell line, and supports GHs involvement in differentiation, while altering cell metabolism in preparation for synthesis and secretion of milk components.

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis.

The relevance of nuclear and extranuclear localization of ERs and other eventual estrogen binding sites, mediating differential actions in regard to these various topics is critically addressed to delineate the importance of direct and indirect activation procedures and delicate feedback loops.

Endocrinology of milk production.




Growth control and differentiation in mammary epithelial cells.

Complete or partial sequencing of several milk protein genes and comparative analysis have led to identification of a sequence of high homology and conservation in the 5' flanking region that is likely to be involved in the regulation of milk protein gene expression.

The mammary gland.

  • I. Forsyth
  • Biology, Medicine
    Bailliere's clinical endocrinology and metabolism
  • 1991

Growth Factors, Apoptosis, and Survival of Mammary Epithelial Cells

A complexdynamic pattern of cell death-inducing and survivalfactors that promote the development of the maturemammary gland and that rapidly remodel the tissue afterlactation is described.

Expression of transforming growth factors alpha and beta-1 messenger RNA in the bovine mammary gland during different stages of development and lactation.

It can be assumed that growth promoting TGF-alpha and growth inhibiting T GF-beta 1 are co-expressed in the bovine mammary gland.

Role of epidermal growth factor in the acquisition of ovarian steroid hormone responsiveness in the normal mouse mammary gland

Evidence is provided that E‐dependent responses of mouse mammary gland in vivo, such as end‐bud proliferation and PR regulation, may be mediated by EGF through an ER‐dependent mechanism.

Establishing a Framework for the Functional Mammary Gland: From Endocrinology to Morphology

Defining the hormonal control of ductal development should facilitate a better understanding of the mechanisms underlying mammary gland tumorigenesis and provide the opportunity to further delineate the regulation ofductal development.

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

It is demonstrated that IGF-I and IGFBP-3 may modulate the involutionary process of the lactating mammary gland by influencing the remodeling of mammary tissue during involution.

Role of prolactin, growth hormone and insulin-like growth factor 1 in mammary gland involution in the dairy cow.

A relationship between levels of apoptosis and IGFBP-5 mRNA expression in the bovine mammary gland is demonstrated and the involvement of this binding protein programmed cell death and its relationship with the main lactogenic hormones is confirmed.

A Reappraisal of Progesterone Action in the Mammary Gland

The identification of paracrine mediators of the progesterone response is now an imminent goal as is the delineation of the individual contributions of the two PR isoforms using similar approaches.

The insulin-like growth factor and epidermal growth factor families in mammary cell growth in ruminants: action and interaction with hormones.

  • I. Forsyth
  • Biology, Medicine
    Journal of dairy science
  • 1996
These findings suggest that the drive to mammary development in pregnancy comes from control of growth factors, and, in the case of IGF, modulating binding proteins, a control exerted by hormones, which, in general, are not themselves mitogens.