Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution

@article{Lamote2004SexSA,
  title={Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution},
  author={Inge Lamote and Evelyne Meyer and Anne-Marie Massart-Le{\"e}n and Christian Burvenich},
  journal={Steroids},
  year={2004},
  volume={69},
  pages={145-159}
}

3 – Mammary Gland

Role of ovarian secretions in mammary gland development and function in ruminants.

The role and the importance of ovarian steroids on mammary gland and on MECs is described and ovarian steroids appear to be key regulators of the different stages of mammogenesis and mammary function.

Age-Related Changes in the Epithelial and Stromal Compartments of the Mammary Gland in Normocalcemic Mice Lacking the Vitamin D3 Receptor

Developmental studies indicate that, under normocalcemic conditions, loss of VDR signaling is associated with age-related estrogen deficiency, disruption of epithelial ductal branching, abnormal energy expenditure and atrophy of the mammary adipose compartment.

Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation

The concept of cellular plasticity in normal breast morphogenesis and cancer, and how the stromal environment plays a vital role in cancer initiation and progression is discussed.

Growth hormone alters components related to differentiation, metabolism and milk synthesis and secretion in MAC-T cells

Results indicate that GH is an important factor in inducing a lactogenic phenotype in the MAC-T cell line, and supports GHs involvement in differentiation, while altering cell metabolism in preparation for synthesis and secretion of milk components.

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis.

The relevance of nuclear and extranuclear localization of ERs and other eventual estrogen binding sites, mediating differential actions in regard to these various topics is critically addressed to delineate the importance of direct and indirect activation procedures and delicate feedback loops.

Endocrinology of milk production.

...

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