Sex steroid regulation of insulin-like growth factor system gene expression and proliferation in primate myometrium.

@article{Adesanya1996SexSR,
  title={Sex steroid regulation of insulin-like growth factor system gene expression and proliferation in primate myometrium.},
  author={Oluyemisi O. Adesanya and Jian Zhou and Carolyn A. Bondy},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 5},
  pages={1967-74}
}
To investigate the role of locally produced insulin-like growth factors (IGFs) in sex steroid-induced growth in the primate uterus, ovariectomized rhesus monkeys were treated with placebo (control), estradiol (E2) alone, or E2 plus progesterone (P4). After 2 weeks, uteri were removed, and serial thin uterine sections were analyzed by in situ hybridization for IGF-I, IGF-II, and IGF-I and -II receptor messenger ribonucleic acids (mRNAs) and by immunocytochemistry for the cell proliferation… CONTINUE READING
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