Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?

@article{Copland2009SexSR,
  title={Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?},
  author={J. Copland and M. Sheffield-Moore and N. Koldzic-Zivanovic and S. Gentry and G. Lamprou and F. Tzortzatou-Stathopoulou and V. Zoumpourlis and R. Urban and Spiros A Vlahopoulos},
  journal={BioEssays},
  year={2009},
  volume={31}
}
  • J. Copland, M. Sheffield-Moore, +6 authors Spiros A Vlahopoulos
  • Published 2009
  • Medicine, Biology
  • BioEssays
  • Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with… CONTINUE READING

    Topics from this paper.

    Drugs acting on homeostasis: challenging cancer cell adaptation
    • 13

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 130 REFERENCES
    Ligand-independent activation of steroid hormone receptors
    • 331
    Mechanisms of sex steroid effects on bone.
    • 340
    • Highly Influential
    Transcriptional activation and nuclear targeting signals of the human androgen receptor.
    • 461
    Mechanisms of action of steroid hormones.
    • 265
    • Highly Influential
    Exploring the role of sex steroids through studies of receptor deficient mice
    • 90
    • PDF
    Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor.
    • 169
    • PDF