Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?

  title={Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?},
  author={John A. Copland and Melinda Sheffield-Moore and Nina Koldzic-Zivanovic and Sean Gentry and George K. Lamprou and Fotini Tzortzatou-Stathopoulou and Vassilis Zoumpourlis and Randall J. Urban and Spiros A Vlahopoulos},
Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with… 
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