Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).

@article{Swanson2007SexSL,
  title={Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).},
  author={Charlotte Swanson and Mattias Lorentzon and Liesbeth Vandenput and Fernand Labrie and Anders Rane and Jenny Jakobsson and Sarah Chouinard and Alain B{\'e}langer and C Ohlsson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 9},
  pages={3697-704}
}
CONTEXT Sex steroids are involved in the regulation of pubertal cortical bone expansion in males. In vitro studies have indicated that the enzyme uridine diphosphate glucuronosyltransferase (UGT) 2B7 has the capacity to glucuronidate sex steroids and their metabolites. OBJECTIVE Our objective was to determine the impact of the H(268)Y polymorphism in the UGT2B7 gene on interindividual variation of serum levels of sex steroids and cortical bone dimensions. PARTICIPANTS The population-based… CONTINUE READING
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