Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators

  title={Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators},
  author={Lotta Andr{\'e}en and Sigrid Nyberg and S. Turkmen and Guido A. van Wingen and Guill{\'e}n Fern{\'a}ndez and Torbj{\"o}rn B{\"a}ckstr{\"o}m},

Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder

The underlying studies of this review provide evidence that allopregnanolone is the provoking factor behind the negative mood symptoms in PMDD and that isoallopreg nanolone could ameliorate the symptoms as a result of its ability to antagonise the allopreginolone effect on the GABAA receptor.

The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders

GABAAR plasticity associated with alterations in neurosteroid levels represents a homeostatic compensatory mechanism to maintain an ideal level of inhibition to offset the potentiating effects of neurosteroids on GABAergic inhibition.

Sex and estrous cycle influence diazepam effects on anxiety and memory: Possible role of progesterone

Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle

GA-inhibitory function fluctuates across the menstrual cycle and is reduced perinatally, which has potential implications for a role of GABAergically mediated interventions in the prevention and treatment of menstrual cycle-related and perinatal depressive disorders.

Multifunctional aspects of allopregnanolone in stress and related disorders

  • Anjana BaliA. Jaggi
  • Biology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2014

Effects of acute progesterone administration upon responses to acute psychosocial stress in men.

Progesterone dampened some of the psychological effects of stress but produced inconsistent effects on physiological stress responses, as shown in the chart below.

Hormesis and Female Sex Hormones

Examples of female sexual steroids demonstrating bidirectional dose-response relations and to discuss this in the perspective of hormesis are reviewed, including the effects on cerebral ischemia, inflammation, cardiovascular diseases and anxiety.



The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome

SSRIs and substances inhibiting ovulation, such as gonadotrophin-releasing hormone (GnRH) agonists, have proven to be effective treatments and add-back hormone replacement therapy is recommended to avoid adverse effects when high dosages of GnRH agonists are sed.

Progesterone selectively increases amygdala reactivity in women

Investigating whether a single progesterone administration to healthy young women in their follicular phase modulates the amygdala response to salient, biologically relevant stimuli reveals a neural mechanism by which progester one may mediate adverse effects on anxiety and mood.

Oral contraceptives and mood in women with and without premenstrual dysphoria: a theoretical model

It is argued that progestins exert differential effects on endogenous levels of neurosteroids, thereby altering mood, and the possibility that fluctuations in neurosteroid levels are responsible for the effects of oral contraceptives on mood is investigated.

Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers.

Plasma allopregnanolone and pregnanolone was significantly correlated with measures of fatigue, confusion and immediate recall, and these correlation coefficients were somewhat greater than those for plasma progesterone and these same behavioral measures.

Increase of estrogen dose deteriorates mood during progestin phase in sequential hormonal therapy.

The conclusion is that an increase of the estrogen dose accentuates negative mood and physical symptoms during the progestin phase of sequential hormonal therapy.

The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome

The symptoms were similar to the typical complaints of the premenstrual syndrome, such that a combination of oestradiol and testosterone implants with cyclical oral norethisterone appears to be a model for this condition.

Allopregnanolone concentration and mood—a bimodal association in postmenopausal women treated with oral progesterone

Mood effects during progesterone treatment seem to be related to allopregnanolone concentration, and a bimodal association between allopreginolone and adverse mood is evident.