Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators

  title={Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators},
  author={L. Andr{\'e}en and S. Nyberg and Sharuh Turkmen and G. Wingen and T. B{\"a}ckstr{\"o}m},
  • L. Andréen, S. Nyberg, +2 authors T. Bäckström
  • Published 2009
  • Psychology, Medicine
  • Psychoneuroendocrinology
  • UNLABELLED Certain women experience negative mood symptoms as a result of progesterone during the luteal phase of the menstrual cycle, progestagens in hormonal contraceptives, or the addition of progesterone or progestagens in sequential hormone therapy (HT). This phenomenon is believed to be mediated via the action of the progesterone metabolites on the GABA(A) system, which is the major inhibitory system in the mammalian CNS. The positive modulators of the GABA(A) receptor include… CONTINUE READING
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