Sex steroid hormones change the differential distribution of the isoforms of the D2 dopamine receptor messenger RNA in the rat brain.

@article{Guivarch1995SexSH,
  title={Sex steroid hormones change the differential distribution of the isoforms of the D2 dopamine receptor messenger RNA in the rat brain.},
  author={Dominique Guivarc'h and Philippe Vernier and J. D. Vincent},
  journal={Neuroscience},
  year={1995},
  volume={69 1},
  pages={159-66}
}
The two isoforms of the rat dopamine D2 receptor are generated by alternative splicing of the pre-messenger RNA and differ in the length of their third cytoplasmic loop involved in coupling to G-proteins. As quantified by polymerase chain reaction, the long isoform D2L is predominant in the pituitary gland, the striatum and to a lesser extend in the olfactory tubercle, whereas the short isoform D2S is relatively more abundant in the hypothalamus and the substantia nigra. Changes in circulating… CONTINUE READING
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