Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men.

@article{Finkelstein1991SexSC,
  title={Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men.},
  author={Joel S. Finkelstein and Rebekah Whitcomb and L S O'Dea and Christopher Longcope and David A. Schoenfeld and William Francis Crowley},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={73 3},
  pages={609-20}
}
The precise sites of action of the negative feed-back effects of gonadal steroids in men remain unclear. To determine whether testosterone (T) administration can suppress gonadotropin secretion directly at the level of the pituitary, the pituitary responses to physiological doses of GnRH were assessed in six men with complete GnRH deficiency, whose pituitary-gonadal function had been normalized with long term pulsatile GnRH delivery, before and during a 4-day continuous T infusion (15 mg/day… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis.

American journal of physiology. Endocrinology and metabolism • 1998
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…