Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice.

Abstract

Cytotoxic antineoplastic therapy is used to treat malignant disease but results in long-term immunosuppression in postpubertal and adult individuals, leading to increased incidence and severity of opportunistic infections. We have previously shown that sex steroid ablation (SSA) reverses immunodeficiencies associated with age and hematopoietic stem cell… (More)
DOI: 10.4049/jimmunol.0802445

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