Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila.

@article{Coschigano1993SexspecificTR,
  title={Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila.},
  author={K T Coschigano and Pieter C. Wensink},
  journal={Genes & development},
  year={1993},
  volume={7 1},
  pages={
          42-54
        }
}
The somatic sexual phenotype of Drosophila is regulated by the sexual differentiation pathway. Male (DSXM) and female (DSXF) proteins encoded by doublesex (dsx), a gene at the end of this pathway, bind to three sites within a 127-bp enhancer that directs sex- and tissue-specific transcription of Yolk protein genes. We describe mutagenesis of these binding sites and the resulting effects on DSXM and DSXF binding in vitro and on gene regulation in wild-type and dsx mutant flies. The results… CONTINUE READING
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