Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons

@article{Kimoto2005SexspecificPF,
  title={Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons},
  author={H. Kimoto and Sachiko Haga and Koji Sato and K. Touhara},
  journal={Nature},
  year={2005},
  volume={437},
  pages={898-901}
}
In mammals, social and reproductive behaviours are modulated by pheromones, which are chemical signals that convey information about sex and strain. The vomeronasal organ, located at the base of the nasal septum, is responsible for mediating pheromone information in mice. Two classes of putative pheromone receptor gene families, V1R and V2R, are expressed by vomeronasal sensory neurons in mutually segregated epithelial zones of the vomeronasal organ. Although numerous studies have suggested… Expand
Structure and function of a peptide pheromone family that stimulate the vomeronasal sensory system in mice.
TLDR
The discovery of a 7 kDa peptide, ESP1 (exocrine-gland-secreting peptide 1), in tear fluids from male mice that enhances the sexual behaviour of female mice via the VNO and a structural basis for the narrowly tuned perception of mammalian peptide pheromones by vomeronasal receptors is indicated. Expand
Sex- and Strain-Specific Expression and Vomeronasal Activity of Mouse ESP Family Peptides
TLDR
Sexual dimorphism and strain differences of ESPs and their reception in the VNO suggest that the ESP family can convey information about sex and individual identity via the vomeronasal system. Expand
The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
TLDR
The findings show that ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system, and enhances female sexual receptive behaviour upon male mounting, allowing successful copulation. Expand
In-vivo activation of vomeronasal neurons shows adaptive responses to pheromonal stimuli
TLDR
It is found that a consistent proportion of VSNs is activated by both heterospecific and intraspecific pheromones, and there is evidence of adaptive responses to S6 phosphorylation when stimulation with cues of the same and opposite sex and of different species is sustained. Expand
Molecular biology of peptide pheromone production and reception in mice.
  • K. Touhara
  • Biology, Medicine
  • Advances in genetics
  • 2007
TLDR
This chapter will review the current knowledge on genetic and molecular aspects of peptide pheromone-mediated communication via the vomeronasal pathway in mice by focusing primarily on the mouse VNO system. Expand
The genomic basis of vomeronasal-mediated behaviour
TLDR
The vomeronasal organ mediates a range of social behaviours, including male–male and maternal aggression, sexual attraction, lordosis, and selective pregnancy termination, as well as interspecific responses such as avoidance and defensive behaviours. Expand
Pheromone sensing in mice.
TLDR
These mouse models suggest that both the main and the accessory olfactory systems can converge and synergize to express the complex array of stereotyped behaviors and hormonal changes triggered by pheromones. Expand
Imaging neuronal responses in slice preparations of vomeronasal organ expressing a genetically encoded calcium sensor.
TLDR
Transgenic mice that express G-CaMP2 in the olfactory sensory neurons, including the VSNs are developed and the sensitivity and the genetic nature of the probe greatly facilitate Ca2+ imaging experiments. Expand
In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb
TLDR
It is found that urine, a well-characterized pheromone source in mammals, activates AOB neurons in a manner that reliably encodes the donor animal’s sexual and genetic status, thereby supporting the notion of integrative processing of chemosensory information. Expand
Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice
TLDR
It is demonstrated that the male pheromone exocrine gland-secreting peptide 1 (ESP1) is one of the key factors that causes pregnancy block and Prolactin surges in the blood after mating were suppressed by ESP1 exposure, suggesting that a neuroendocrine mechanism underlies ESP1-mediated pregnancy failure. Expand
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