Sex-specific neuroendocrine and behavioral phenotypes in hypomorphic Type II Neuregulin 1 rats.

@article{Taylor2011SexspecificNA,
  title={Sex-specific neuroendocrine and behavioral phenotypes in hypomorphic Type II Neuregulin 1 rats.},
  author={Sara Taylor and Julie A. Markham and Adam R. Taylor and Brooke Z Kanaskie and James I. Koenig},
  journal={Behavioural brain research},
  year={2011},
  volume={224 2},
  pages={223-32}
}
Neuregulin 1 (NRG1) is an important growth factor involved in the development and plasticity of the central nervous system. Since its identification as a susceptibility gene for schizophrenia, several transgenic mouse models have been employed to elucidate the role NRG1 may play in the pathogenesis of psychiatric disease. Unfortunately very few studies have included females, despite the fact that some work suggests that the consequences of disrupted NRG1 expression may be sex-specific. Here, we… CONTINUE READING

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