Sex-specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes.

@article{Kasper1999SexspecificIO,
  title={Sex-specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes.},
  author={P. Kasper and L. Mueller},
  journal={Carcinogenesis},
  year={1999},
  volume={20 11},
  pages={
          2185-8
        }
}
The synthetic steroid cyproterone acetate (CPA) has been reported to be hepatogenotoxic in female rats depending on sex-specific expression of a hydroxysteroid sulfotransferase (HST) which is involved in the bioactivation of CPA to reactive metabolites. In the present study the ability of CPA to initiate apoptosis in rat hepatocytes in vitro was investigated with respect to sex-specific effects and dependency on HST activity. Incubation of primary hepatocytes of female rats with CPA (0.1-30… Expand
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