Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure.

@article{Kundakovi2013SexspecificED,
  title={Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure.},
  author={Marija Kundakovi{\'c} and Kathryn M A Gudsnuk and Becca Franks and Jesus E Madrid and Rachel L Miller and Frederica Perera and F. Champagne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 24},
  pages={
          9956-61
        }
}
Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechanisms underlying these effects are unknown. We hypothesized that BPA may disrupt epigenetic programming of gene expression in the brain. Here, we provide evidence that maternal exposure during pregnancy to environmentally relevant doses of BPA (2, 20, and 200 µg/kg/d) in mice… CONTINUE READING

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Agency (1988) Bisphenol A (CASRN 80-05-7)

  • US Environmental Protectio
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