Sex-specific differences in neonatal hyperoxic lung injury.

@article{Lingappan2016SexspecificDI,
  title={Sex-specific differences in neonatal hyperoxic lung injury.},
  author={Krithika Lingappan and Weiwu Jiang and Lihua Wang and Bhagavatula Moorthy},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2016},
  volume={311 2},
  pages={
          L481-93
        }
}
Male sex is considered an independent predictor for the development of bronchopulmonary dysplasia (BPD) after adjusting for other confounders. BPD is characterized by an arrest in lung development with marked impairment of alveolar septation and vascular development. The reasons underlying sexually dimorphic outcomes in premature neonates are not known. In this investigation, we tested the hypothesis that male neonatal mice will be more susceptible to hyperoxic lung injury and will display… CONTINUE READING

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