Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh.

@article{Niedzwiecki2015SexspecificAO,
  title={Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh.},
  author={Megan M Niedzwiecki and Xinhua Liu and Megan N. Hall and Tiffany A. Thomas and Vesna N Slavkovich and Vesna Ilievski and Diane Levy and Shafiul Alam and Abu Baker Siddique and Faruque Parvez and Joseph H. Graziano and M. Gamble},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2015},
  volume={24 11},
  pages={1748-57}
}
BACKGROUND Depletion of global 5-hydroxymethylcytosine (5-hmC) is observed in human cancers and is strongly implicated in skin cancer development. Although arsenic (As)-a class I human carcinogen linked to skin lesion and cancer risk-is known to be associated with changes in global %5-methylcytosine (%5-mC), its influence on 5-hmC has not been widely studied. METHODS We evaluated associations of As in drinking water, urine, and blood with global %5-mC and %5-hmC in two studies of Bangladeshi… CONTINUE READING
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