Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.

@article{Shen2010SexspecificAO,
  title={Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.},
  author={Nan Shen and Qiong Fu and Yun Zhe Deng and Xiaoxia Qian and Jian Zhao and Kenneth M Kaufman and Yee Ling Wu and Chack Yung Yu and Yuanjia Tang and Ji-Yih Chen and Wanling Yang and Maida Wong and Aya Kawasaki and Naoyuki Tsuchiya and Takayuki Sumida and Yasushi Kawaguchi and Hwee Siew Howe and Mo Yin Mok and So-Young Bang and Fei-Lan Liu and Deh-Ming Chang and Yoshinari Takasaki and Hiroshi Hashimoto and John B Harley and Joel M Guthridge and Jennifer M. Grossman and Rita M . Cantor and Yeong Wook Song and Sang-Cheol Bae and Shunle Chen and Bevra Hannahs Hahn and Yu Lung Lau and Betty P Tsao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 36},
  pages={
          15838-43
        }
}
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women. Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE. By using a candidate gene approach, we identified and replicated association of a TLR7 3'UTR SNP, rs3853839 (G/C), with SLE in 9,274 Eastern Asians (P(combined) = 6.5 x 10(-10)), with a stronger effect in male than female subjects [odds ratio… CONTINUE READING
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