Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity.

@article{Bennett1982SexrelatedDI,
  title={Sex-related differences in the susceptibility of rats to gentamicin nephrotoxicity.},
  author={William Bennett and Robert A. R. Parker and Wynne Elliott and David N. Gilbert and Donald C. Houghton},
  journal={The Journal of infectious diseases},
  year={1982},
  volume={145 3},
  pages={
          370-3
        }
}
Age-matched male and female Fischer 344 rats were treated with gentamicin, 40 mg/kg of animal body weight per day, for three to 21 days. Renal dysfunction was less severe in females as measured by concentrations of blood urea nitrogen and creatinine and by cortical slice uptake of p-aminohippuric acid and N1-methylnicotinamide chloride. Also, cortical concentrations of gentamicin in females were lower than in males. Neither exogenous testosterone administered to adult females nor castration of… CONTINUE READING
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