Sex-related differences in mechanical nociception and antinociception produced by mu- and kappa-opioid receptor agonists in rats.

@article{Barrett2002SexrelatedDI,
  title={Sex-related differences in mechanical nociception and antinociception produced by mu- and kappa-opioid receptor agonists in rats.},
  author={Andrew C. Barrett and E Suzanne Smith and Mitchell J. Picker},
  journal={European journal of pharmacology},
  year={2002},
  volume={452 2},
  pages={163-73}
}
Previous studies indicate that in antinociceptive procedures employing thermal, chemical and electrical stimuli, opioids are generally more potent in male than female rodents. The purpose of the present study was to examine nociception and opioid antinociception in male and female rats using a mechanical nociceptive stimulus. Results indicated that males had a higher threshold for nociception, and in tests in which a constant pressure was applied to the hindpaw, the paw withdrawal latencies… CONTINUE READING

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