Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats.

@article{Lei2011SexrelatedDI,
  title={Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats.},
  author={Jing Lei and Lin Jin and Ye Zhao and Mei-Yu Sui and Li Huang and Yong-Xiang Tan and Yan-Ke Chen and Hao-Jun You},
  journal={Experimental neurology},
  year={2011},
  volume={228 2},
  pages={206-14}
}
Sex-associated differences in the perception and modulation of pain have widely been reported in humans as well as animals. The aim of the present study performed in conscious rats of both sexes was to systematically investigate the role of sex in endogenous descending controls of nociceptive paw withdrawal reflex during experimental muscle pain elicited by intramuscular (i.m.) injection with different doses (0.1-0.4 ml of 0.9-5.8%) of saline. Ipsilateral i.m. injection of 0.2-0.4 ml, but not 0… CONTINUE READING
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