Sex ratio and unisexual sterility in hybrid animals

  title={Sex ratio and unisexual sterility in hybrid animals},
  author={John Burdon Sanderson Haldane},
  journal={Journal of Genetics},
  • J. Haldane
  • Published 1 October 1922
  • Biology
  • Journal of Genetics
SummaryWhen in theF1 offspring of a cross between two animal species or races one sex is absent, rare, or sterile, that sex is always the heterozygous sex. 

Correction to: Hybrid sterility increases with genetic distance in snubnose darters (Percidae: Etheostoma)

The original version of this article unfortunately contained a mistake. The correct equation is now given below.

Does the speciation clock tick more slowly in the absence of heteromorphic sex chromosomes?

  • B. PhillipsS. Edmands
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2012
Squamates may be an attractive group in which to study the influence of sex chromosomes on speciation rates because of the repeated evolution of heterogamety (both XY and ZW), as well as an

Physiological Sex Predicts Hybrid Sterility Regardless of Genotype

Gene expression profiles match these adult phenotypes and demonstrate that faster-male evolution is the most likely mechanism producing hybrid male sterility.

Introduction: Sex chromosomes and speciation

One implication of particular evolutionary significance is that sex chromosomes play an outsized role in speciation - the process by which one species becomes two.

Speciation and reduced hybrid female fertility in house mice

Differences in reproductive phenotypes in reciprocal genotypes were observed and are consistent with cyto‐nuclear incompatibilities or incomp atibilities involving genomic imprinting, highlighting the potential importance of reduced hybrid female fertility in the early stages of speciation.

A Novel Approach Identifying Hybrid Sterility QTL on the Autosomes of Drosophila simulans and D. mauritiana

A novel approach employing attached-X chromosomes to create reciprocal backcross interspecies hybrid males that have a non-recombinant sex chromosome and recombinant autosomes is used, thereby allowing us to accurately identify the number and location of autosomal sterility loci.

Gene Mapping in Ficedula Flycatchers

In order to get full understanding of how evolution proceeds in natural settings it is necessary to reveal the genetic basis of the phenotypic traits that play a role for individual fitness in diff

Species-Specific Heterochromatin Prevents Mitotic Chromosome Segregation to Cause Hybrid Lethality in Drosophila

Early embryonic lethality of interspecies hybrids in Drosophila can be caused by defects in mitotic segregation of paternal X chromatids carrying a critical domain of heterochromatic DNA.

Apparent changes with age in crossing-over between colour and size genes in mice

Changes in the values of the brown-black mean weight ratios in the back-cross populations of a mouse species cross support the view that crossing-over between size and colour genes increases with age in the female and decreases in the male.

Extreme heterochiasmy and nascent sex chromosomes in European tree frogs

The results support the pleiotropic model of Haldane and Huxley, according to which recombination is reduced in the heterogametic sex by general modifiers that affect recombination on the whole genome.



Note on a case of linkage inParatettix

Linkage between two Mendelian colour factors occurs in Paratettix texanus, the cross-over value being about 24% in the male, 46% inThe female, probably more intense in triply than in doubly heterozygous animals.

On sterile and hybrid pheasants

Evidence is brought forward to show that the sterility of the male and female hybrid pheasants is due to abnormalities occurring at the synapsis stage of the reduction division, with a large preponderance of males over females.

Studies in the hybridbistoninae

Inbreeding and its effects in inducing the appearance of females in broods which, according to expectation, should have been unisexual and male are studied.


In a former paper' I have noted the difficulty of obtaining female hybrids from pigeons or doves of widely different parent age. Of the seven hybrid offspring of very distinct species then in hand,

Parthenogenesis and Crossing-Over in the Grouse Locust Apotettix

In these experiments, involving several hundred kinds of matings and many thousands of individuals, with only the two exceptions, both as yet unexplained, segregation has taken place as expected.

Genetical studies in the moths of the geometrid genusOporabia (Oporinia) with a special consideration of melanism in the lepidoptera

Introductory Variat ion--Subspecies--Local Raccs -Mchmism; Breeding Experiences; Sex-linked inheritance; Hybridisat ion experiments.

The inheritance of melanism in the genus Tephrosia (Ectropis) with some consideration of the inconstancy of unit characters under crossing

The whole matter seems to hinge on the validity of Gray's definition of a specie~ most of the disputants, alt!lough probably not aware that Gray had ever used the phrase, ~u'gued as if it were perfectly~.

Studies in the hybridbistoninae

Table of pair ings Descr~l)tion of the hybrids showsroduction Factors determining successful product ion o f hybrids, eOc.