Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis.

@article{Colaizzo2011SexMO,
  title={Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis.},
  author={Donatella Colaizzo and Giovanni L Tiscia and Valeria Bafunno and Lucio Amitrano and Patrizia Vergura and Maria Rosaria Lupone and Elvira Grandone and Maria Anna Guardascione and Maurizio Margaglione},
  journal={Thrombosis research},
  year={2011},
  volume={128 3},
  pages={233-6}
}
BACKGROUND The JAK2 V617F mutation is an independent risk factor for MPN and SVT. Gender-related differences in MPN distribution have been reported and, recently, variability in the JAK2 V617F allele burden between sexes has been suggested. We wondered whether gender would modulate the role of the JAK2 V617F mutation as susceptibility risk factor for SVT. MATERIALS AND METHODS In 180 patients presenting with SVT, medical history was collected. The presence of the JAK2 V617F mutation and 46/1… CONTINUE READING