Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.

@article{Liu2005SexMT,
  title={Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.},
  author={Tong Liu and B R Choi and M D Drici and Guy Salama},
  journal={Journal of cardiovascular electrophysiology},
  year={2005},
  volume={16 5},
  pages={516-24}
}
Females have a greater susceptibility to Torsade de Pointes in congenital and drug-induced long QT syndrome (LQTS) that has been attributed to the modulation of ion channel expression by sex hormones. However, little is known regarding sex differences in pre-puberty, that is, before the surge of sexual hormones. In patients with congenital LQTS types 1 and 2, male children tend to have a greater occurrence of adverse events, especially in 10-15 year olds, than their female counterpart. To… CONTINUE READING
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