Sex modifies exercise and cardiac adaptation in mice.

  title={Sex modifies exercise and cardiac adaptation in mice.},
  author={John P. Konhilas and Alexander H. Maass and Stephen W. Luckey and Brian L Stauffer and Eric N Olson and L. A. Leinwand},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={287 6},
How an individual's sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological cardiac adaptation in response to voluntary and forced exercise. We found that sex/gender is a dominant factor in exercise performance (in two exercise paradigms and two mouse strains) and that females of one of these strains have greater capacity to increase their cardiac mass in response to similar amounts of… CONTINUE READING
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